Testing for TRK and other Targeted Mutations in Pediatric Cancers

Presented by Jessica L. Davis

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This event is supported by an educational grant from Bayer

Scientific Papers

 
Infantile Fibrosarcoma Spectrum 3.jpg
Infantile NTRK-associated Mesenchymal Tumors
Infantile Fibrosarcoma Pan-TRK.jpg
Testing algorithm for identification of patients with TRK fusion cancer
Infantile Fibrosarcoma Spectrum 2.jpg
Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas
Infantile Fibrosarcoma.jpg
Pan-Trk Immunohistochemistry Identifies NTRK Rearrangments in Pediatric Mesenchymal Tumors
Infantile Fibrosarcoma Spectrum 1.jpg
Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors

Stains

Stains

Pan-TRK (EPR17341) [NTRK]

Features

Pathophysiology

  • NTRK gene fusions (NTRK1/2/3) to a variety of gene partners are oncogenic drivers in several tumor types

  • In some tumor morphologies, NTRK fusions occur at a high frequency:

    • Infantile fibrosarcoma and other pediatric NTRK rearranged mesenchymal tumors

    • Cellular congenital mesoblastic nephroma

    • Secretory carcinomas (breast, salivary gland mammary analog secretory carcinoma and skin)

    • Lipofibromatosis-like neural tumor

    • Uterine sarcomas with NTRK fusions resembling fibromatosis

  • In some pediatric tumors, NTRK fusions occur with intermediate frequency:

    • Pediatric gliomas, pediatric papillary thyroid carcinoma, Spitz nevi

  • In other tumors, NTRK fusions occur very infrequently:

    • Adult gliomas, adult papillary thyroid carcinoma, colorectal carcinoma, lung adenocarcinoma, melanoma, leukemia and less commonly others

  • Recognition of NTRK fusion tumors had become increasingly important with the advent of targeted Trk inhibitors

  • Tumors harboring NTRK1/2 fusions demonstrate cytoplasmic expression; rare perinuclear and nuclear membrane staining has been reported

  • Tumors harboring NTRK3 fusions demonstrate cytoplasmic or nuclear expression

Infantile Fibrosarcoma

Infantile Fibrosarcoma
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Infantile Fibrosarcoma
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Infantile Fibrosarcoma Spectrum of Tumors

Infantile Fibrosarcoma Spectrum
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Infantile Fibrosarcoma Spectrum
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Infantile Fibrosarcoma Spectrum
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Positive Staining

Positive Staining Tumors:

Positive Staining Normal:

Negative Staining

Negative Staining Tumors:

Negative Staining Normal:

 
 

Test your

Pan-TRK (ERP17341) [NTRK]

knowledge