Testing for TRK and other Targeted Mutations in Pediatric Cancers

Presented by Jessica L. Davis

This event is supported by an educational grant from Bayer

Scientific Papers

 
Infantile Fibrosarcoma Spectrum 3.jpg
Infantile NTRK-associated Mesenchymal Tumors
Testing algorithm for identification of patients with TRK fusion cancer
Recurrent BRAF Gene Fusions in a Subset of Pediatric Spindle Cell Sarcomas
Pan-Trk Immunohistochemistry Identifies NTRK Rearrangments in Pediatric Mesenchymal Tumors
Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors

Stains

Stains

Pan-TRK (EPR17341) [NTRK]

Features

Pathophysiology

  • NTRK gene fusions (NTRK1/2/3) to a variety of gene partners are oncogenic drivers in several tumor types

  • In some tumor morphologies, NTRK fusions occur at a high frequency:

    • Infantile fibrosarcoma and other pediatric NTRK rearranged mesenchymal tumors

    • Cellular congenital mesoblastic nephroma

    • Secretory carcinomas (breast, salivary gland mammary analog secretory carcinoma and skin)

    • Lipofibromatosis-like neural tumor

    • Uterine sarcomas with NTRK fusions resembling fibromatosis

  • In some pediatric tumors, NTRK fusions occur with intermediate frequency:

    • Pediatric gliomas, pediatric papillary thyroid carcinoma, Spitz nevi

  • In other tumors, NTRK fusions occur very infrequently:

    • Adult gliomas, adult papillary thyroid carcinoma, colorectal carcinoma, lung adenocarcinoma, melanoma, leukemia and less commonly others

  • Recognition of NTRK fusion tumors had become increasingly important with the advent of targeted Trk inhibitors

  • Tumors harboring NTRK1/2 fusions demonstrate cytoplasmic expression; rare perinuclear and nuclear membrane staining has been reported

  • Tumors harboring NTRK3 fusions demonstrate cytoplasmic or nuclear expression

Infantile Fibrosarcoma

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Infantile Fibrosarcoma Spectrum of Tumors

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Positive Staining

Positive Staining Tumors:

Positive Staining Normal:

Negative Staining

Negative Staining Tumors:

Negative Staining Normal:

 
 

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Pan-TRK (ERP17341) [NTRK]

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